Laboratory diagnosis of neurotuberculosis in Mozambique.
Keywords:
Diagnosis, Neuro-tuberculosis, Diagnosis,Methods and TuberculosisAbstract
Neurotuberculosis is the most lethal form of tuberculosis of the nervous system. Diagnosis generally involves clinical examination, radiological examination and cerebrospinal fluid testing, which is considered the gold standard. The aim of this study was to understand and describe the different methods used to diagnose this disease and to identify the most feasible method in Mozambique. The bibliographic method was favoured, exploratory with a descriptive approach, carried out by searching for data in books, as well as in electronic databases and websites published between 2009 and 2020. The inclusion criterion was the use of up-to-date articles except for books by MISAU, 2007, DF, 2008, Filho, 2008 with full text and publications with data related to the topic under study. All old references were eliminated except for the books mentioned above and publications that did not meet the objectives of the study. Forty-three (43) scientific articles and three (3) websites were used to carry out this work. In view of the above, we identified two groups of tests, such as specific and non-specific tests for the laboratory diagnosis of neurotuberculosis. The first group comprised specific tests that are aimed at identifying Mycobacterium tuberculosis, this group is made up of 5 tests which are bacilloscopy, culture, PCR, TSAQ and TB Ag MPT64. Lately, the 2nd group has included 4 non-specific tests such as haematology, CSF biochemistry, radiology and histopathology. Diagnosis of neurotuberculosis is extremely important because delay in diagnosis and treatment usually leads to serious complications and even death. It also consists of identifying the etiological agent present in biological samples.
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